It is true that some off-label drug use is based on very unsettled science and has more risks. But medicine - and not just cancer care - involves lots of hard choices. And the more serious the disorder, often the more likely it is that for every right and wrong treatment choice there are many other practical decisions painted in shades of gray.

Unhappy and unsettled childhood helps in writing.

Something about John Cleese was always very unsettled, I felt. There was always something else he wanted to do. He seemed constantly driven by this sense that there was a nirvana somewhere; some unique place where mind, body and soul would be utterly satisfied.

Ages when custom is unsettled are necessarily ages of prophecy. The moralist cannot teach what is revealed; he must reveal what can be taught. He has to seek insight rather than to preach.

The question of trademark is pretty unsettled in the open source world. The trademark is important in a consumer product, but there are a few groups who feel it's a restriction they can't live with.

I never understood how one could write a whole book: It is so technically challenging, and it's incredible the way writers put entire worlds inside of them on such a large scale. I tend to have that same feeling when I listen to music - it daunts me and makes me feel quite unsettled listening to so much talent and ambition.

Over the years, Cajun music has always calmed me down, or if I'm feeling real sick or feeling real unsettled, I can put that music on and try to get focused again.

A lot of the time, I write in the third person, but I'm mostly describing my own ordeals. When those unsettled struggles prey on your mind, you become haunted. To get free, you must defeat your ghosts.

Ours is a world which feels so unsettled and dangerous in large ways, whether it's terrorism or global financial meltdown or climate change - huge things that affect us deeply, and yet things about which we can do, individually, very little.

The press gave me a voice too quickly, and that could have unsettled a man who had every right to feel he should be in control of the thing he had created.

I make things complicated for myself and chaotic, so I feel unsettled, and then the challenge is to make something structured and complete emerge from that.

There were periods when I was first-choice keeper and was starting to consolidate my position when out of the blue I got injured. It happened a few times and it really unsettled me.

Whoever has once been truly unsettled by a work of the imagination will never give loyalty to a single idea, belief system, religious faith or party.

Even printed, on pages that are bound, sentences remain unsettled organisms. Years later, I can always reach out to smooth a stray hair. And yet, at a certain point, I must walk away, trusting them to do their work. I am left looking over my shoulder, wondering if I might have structured one more effectively.

I never thought I was writing for kids at all. It really shocked and unsettled me to hear kids were buying the books. If I'd known I was writing for kids, I might actually have spelt things out a bit more, and that would probably have killed the appeal.

I probably wouldn't be a songwriter if I didn't grow up the way I did. It was difficult and it was at times very scary to grow up in a household so unsettled and at times very violent. But, it also, I guess it earned me a sort of wisdom at a young age that's served me well.

My wild and free side unsettled some, and unwedged others.

I never come back home with the same moral character I went out with; something or other becomes unsettled where I had achieved internal peace; some one or other of the things I had put to flight reappears on the scene.

If you remain unsettled by a piece of writing, it means you are not watching the story from the outside; you've already taken a step towards it.

I live quite an unsettled life.